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http://cris.utm.md/handle/5014/295| Title: | Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles | Authors: | BRANISTE, Tudor COBZAC, Vitalie ABABII, Polina PLESCO, Irina RAEVSCHI, Simion DIDENCU, Alexandru NACU, Viorel ABABII, Ion TIGINYANU, Ion |
Keywords: | mesenchymal stem cells;nanoparticles;gallium nitride;cells guiding | Issue Date: | 2020 | Source: | Tudor Braniste, Vitalie Cobzac, Polina Ababii, Irina Plesco, Simion Raevschi, Alexandru Didencu, Mihail Maniuc, Viorel Nacu, Ion Ababii, Ion Tiginyanu, Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles, Biotechnology Reports, Volume 25, 2020, e00435, ISSN 2215-017X, https://doi.org/10.1016/j.btre.2020.e00435. (http://www.sciencedirect.com/science/article/pii/S2215017X19304710) Abstract: In this paper, we report on spatial redistribution of bone marrow mesenchymal stem cells loaded with magnetic nanoparticles under the influence of continuously applied magnetic field. Semiconductor nanoparticles were synthesized by epitaxial growth of a GaN thin layer on magnetic sacrificial core consisting of ZnFe2O4 nanoparticles. Different quantities of nanoparticles were incubated in vitro with mesenchymal stem cells. High density of nanoparticles (50 μg/ml) leads to a decrease in the number of cells during incubation, while the density of nanoparticles as low as 10 μg/ml is enough to drag cells in culture and rearrange them according to the spatial distribution of the magnetic field intensity. Keywords: Mesenchymal stem cells; Nanoparticles; Gallium nitride; Cells guiding | Project: | 19.80012.50.03A. Elaborarea suprafețelor cu grad controlat de hidrofobie datorită nanomicrostructurării NanoMedTwin - Promoting smart specialization at the Technical University of Moldova by developing the field of Novel Nanomaterials for BioMedical Applications through excellence in research and twinning 20.80009.50007.20 |
Journal: | Biotechnology Reports | Abstract: | In this paper, we report on spatial redistribution of bone marrow mesenchymal stem cells loaded with magnetic nanoparticles under the influence of continuously applied magnetic field. Semiconductor nanoparticles were synthesized by epitaxial growth of a GaN thin layer on magnetic sacrificial core consisting of ZnFe2O4 nanoparticles. Different quantities of nanoparticles were incubated in vitro with mesenchymal stem cells. High density of nanoparticles (50 μg/ml) leads to a decrease in the number of cells during incubation, while the density of nanoparticles as low as 10 μg/ml is enough to drag cells in culture and rearrange them according to the spatial distribution of the magnetic field intensity. |
URI: | http://cris.utm.md/handle/5014/295 | ISSN: | 2215017X | DOI: | 10.1016/j.btre.2020.e00435 |
| Appears in Collections: | Journal Articles |
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| File | Description | Size | Format | |
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| 1-s2.0-S2215017X19304710-main.pdf | 1.29 MB | Adobe PDF | View/Open |
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